Enhancing Language Function in Primary Progressive Aphasia (PPA) With Transcranial Direct Current Stimulation (tDCS)
Status: Recruiting
Location: See location...
Intervention Type: Combination product
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study's goal is to use non-invasive brain stimulation (NBS) techniques to treat language impairment associated with Primary Progressive Aphasia (PPA). The purpose of this study is to combine behavioral language intervention with individualized noninvasive brain stimulation techniques, called transcranial direct current stimulation (tDCS) to help the brain reorganize around damage and improve language functions.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 45
Maximum Age: 80
Healthy Volunteers: f
View:
• diagnosed with PPA by neurologist or speech-language pathologist
• speech-language deficit arising from PPA
• native speaker of English Language or equivalent
• adequate vision (normal or corrected to normal)
• adequate hearing
Locations
United States
Arizona
University of Arizona
RECRUITING
Tucson
Contact Information
Primary
Aneta Kielar, PhD
akielar@email.arizona.edu
15204883791
Time Frame
Start Date: 2021-08-30
Estimated Completion Date: 2027-06-15
Participants
Target number of participants: 20
Treatments
Experimental: active TDCS
During intervention excitatory/anodal tDCS will be administered alongside speech-language therapy 5 days a week for 2 weeks. The exact location of the stimulation and electrode configuration will be targeted individually based on the optimal site identified in fMRI. TDCS will be administered with NeurConn1 Channel DC- Stimulator Plus (neuroCare Group, München, Germany) according to established guidelines and procedures. The active tDCS will be delivered for 20 minutes using sponge electrodes with a 30-s ramp-up and ramp-down period
Sham_comparator: sham TDCS
The sham will be administered alongside speech-language therapy 5 days a week for 2 weeks. For sham, stimulation will be ramped up and then down to 0 milliamperes (mA) in the first minute of stimulation. The sham parameters were chosen based on previous reports that the perceived sensations on the skin, such as tingling, fade out in the first 30 s of tDCS
Related Therapeutic Areas
Sponsors
Leads: University of Arizona